Tuberculosis (TB), one of the oldest diseases known to humankind, continues to claim roughly 2 million lives each year. Approximately one-third of the world’s population is infected with Mycobacterium tuberculosis, the bacterium that causes TB. Each year, close to 9 million new TB cases occur. The developing world is the worst affected with over 90% of all TB cases and TB deaths. Tuberculosis kills more youth and adults than any other single infectious agent in the world today.Today, tuberculosis has become the leading cause of death among HIV-infected individuals, accounting for about one-third of AIDS deaths worldwide. The present curriculum was used in a TB course held in Chennai, India in February 2006. As the only course designed specifically for PVOs, we hope that this manual will be used by others wishing to improve the technical quality of TB programs implemented by PVOs.